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enhance elimination (Extracorporeal techniques (Haemoperfusion (coating…

- - - - overcome the Loss of blood cells & activation of the clotting system
      - does not reduce adsorbing capacity
  - - - Thrombosis
      - Hypotension
      - Bleeding due to use of heparin as a systemic anticoagulant
      - Infections (especially Hepatitis)
  - - - 10-25% as effective as hemodialysis
      - slightly more effective than forced diuresis.
    - - Hemorrhage
      - Volume depletion/overload
      - Pain
      - -Perforation of viscus
      - Bacterial peritonitis
      - Electrolyte imbalance
- - - - promotes excretion of weak bases by increasing their ionization “ion trapping” in the renal tubules
    - - intravenous ammonium chloride/ or ascorbic acid to increase urinary pH to 7.5 - 8
    - - acute toxicity of amphetamine, quinine & phencyclidine
  - - - intravenous sodium bicarbonate to increase urinary pH to 7.5 - 8
    - - weak acidic drugs: salicylate, phenobarbitone(barbiturates ) , methotrexate ,...ate ( salt of acids )
    - - promotes excretion of weak acids by increasing their ionization “ion trapping” in the renal tubules