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Adipose tissue 3D model (Sarkanen (study (hASC induced to angiogenesis…
Adipose tissue 3D model
Sarkanen
current limitations
lack of
adequate vascularization
stable and mature vessels
adipose tissue characteristics
secretes angiogenic factors
hASC promote vessel growth, stabilization and maturation
study
hASC induced to angiogenesis
media+GF monoculture
media+GF in coculture
HUVEC
analyzed for
pericytic markers
SM markers
vascular markers
hASC
results
coculture
accelerated proliferation rate
cells self-assembled into multilayered three-dimensional tubular networks
expressed
endoth markers
basement membrane
vessel-supporting cells
contractile properties
mosaic of von Willebrand factor-positive cells
originated from
HUVEC
hASC
hASC
donor and passage dependent ability for tubular network formation
monoculture
pericytic and SM markers present
even without tubules
HUVEC
Loskill
white adipose tissue
structure
media channel
white adipose tissue chamber
connected via small micropores
Zhu et al
integrated adipose-tissue on a chip with macrophages
properties
LSPR biosensor
antibody conjugated gold nanorod barcode microarrays
cells
adipocyte
crown-like structures
macrophages