Kwan_Isabel_MM9
Mendel's Laws of Inheritance
2nd Law of Inheritance: INDEPENDENT ASSORTMENT
3rd Law of Inheritance: DOMINANCE
1st Law of Inheritance: SEGREGATION
during gamete formation, a paired set of alleles for a given gene will separate into two different gametes
the diploid cell (2n) is split 50:50 so it produces 2 haploid (n) gamete cells
during gamete formation, alleles for different genes sort independently of each other
the diploid (2n) cell is split 25:25:25:25 so it produces 4 haploid (2n) gamete cells
the diploid cell has 2 chromosomes (1 pair of 2), so the haploid cell has 1 chromosome
the diploid cell has 4 chromosomes (2 pairs of 2), so the haploid cells has 2 chromosomes
EXCEPTIONS TO SEGREGATION
genes on different chromosomes are unlinked and will always sort independently
genes on the same chromosome are linked and will only sort independently when crossover causes a chromosomal break between them
the frequency of linked genes sorting independently varies directly with the chromosomal distance between them
VOCABULARY
P Generation: true-breeding (parental generation) that are different from each other
F1 Generation: the P generation hybrid offspring (first filial generation) ALL ARE HYBRID
F2 Generation: the offspring of the F1 generation (second filial generation)
Alleles: the alternative version of genes that account for variations in inherited characters (alternate versions of a gene)
Trait: each variant of for a character (the specific colors)
Character: a heritable feature (color, texture)
Phenotype: an organism's visible traits
Genotype: genetic makeup
Testcross: used to determine the genotype of an individual that expresses the dominant phenotype (RR x rr)
Monohybrids: a mating experience between two individuals to observe how their combination of alleles for a single gene will distribute to the f1 or f2 generation
Dihybrid: (heterozygous for both characteristics) a mating experience between two individuals to observe how their combination of alleles for two genes will distribute to the F1 or F2 generation
Probability Rules
if any recessive offspring appear from the test cross, the dominant individual must be heterozygous.
If not, it is assumed to be homozygous
when more than 2 genes are involved in a cross probability rules are used to reliably predict the outcomes of these crosses
the 2 important probability rules for multi-gene crosses are the product rule and the sum rule
PRODUCT RULE
SUM RULE
p(AxB) = p(A) x p(B)
if the probability of for the independent events of A and B are p(A) OR p(B)
p(A+B) = p(A) + p(B)
if the probability of for the independent events of A and B are p(A) AND p(B)
Non-Mendelian Genetics
Males hemizygosity for sex-linked genes
Gene linkage
Nondisjunction of homologous chromosomes during gamete formation.
Inheritance of mitochondrial DNA
Polygenic traits displays a bell curve distribution
The maternal effect (discussed in later lectures)
Variation in the degree of dominance (i.e., codominance or incomplete dominance)
Sex-Linked Genes
Degree of Dominance
Complete Dominance
Incomplete Dominance
Codominance
A situation where both alleles are equally expressed in the heterozygous state.
The heterozygotes have both red and white colors.
Complete dominance
A situation where the dominant allele completely masks the effect of the recessive allele in the heterozygous state. If the red allele (R) is dominant over white (r), heterozygotes (Rr) will turn out red.
A situation where both alleles are expressed, but unequally so that a blended phenotype is produced. The heterozygotes are pink, a blend of red and white.
Males with only 1 copy of the allele for a recessive sex-linked condition are affected.
Most sex-linked genes are located on the larger X chromosome
Sex-linked genes are gene that are located on either of the sex chromosomes (X or Y)
The pattern of expression of sex-linked recessive traits in males differ from females because females have 2 copies of all sex-linked genes while males have only one copy.
Heterozygous females will have a mixed phenotype because of X-chromosome inactivation