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MT1 (Action Potential (Voltage-gated ion channel (How it works:
voltage…
MT1
Action Potential
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Process: 1) Resting, 2) Depolarize, 3) Hyperpolorize, 4) Polarize
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Reaching Axon Terminal
When an action potential arrives in the presynaptic axon terminal:
1) voltage-gated calcium channels open,
2) calcium causes vesicles to fuse and dump neurotransmitter into the synaptic cleft
3) Neurotransmitters bind to ligand gated-ion channels
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Field EPSPS
Artifact
An artifact comes from the stimulating electrode current, you would see it with no slice in the bath
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What: Measure of the strength of a population of synapses. It reflects the depolarization of many synapses
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Long-Term Potentiation
Induction
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Block AMPA, post-induction, during expression
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Glutamatergic receptors
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1) AMPA open alone (depolarizing spine head; MG2+ block leaves;
2) Then NMDA can open with AMPA = bigger depolarization
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Induction vs. Expression
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Expression (NMDA): NMDA (need to strengthen the connection); NMDA lets in CA; NMDA triggers AMPA; AMPA re-expresses
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Delayed Non-match sample: Reward the opposite object, hold in their memory what the old object is and inhibit that so that they can get the new object (often seen in chimpanzees)
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