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Path - Tumour Markers, Carcinogenesis, Spleen, Thymus, Marrow Disorders (i)
Path - Tumour Markers, Carcinogenesis, Spleen, Thymus, Marrow Disorders (i)
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Gene abnormalities
germline
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inherited loss of allele, subsequent loss of other causes disease
e.g. RB, MEN, colon, melanoma, Li Fraumeni syndrome, some CR + great carcinomas, some malignant melanomas
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CTLA-4 (cytotoxic T cell lymphocyte-associated protein), aka CD152
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