Chlamydia

Gram -ve obligate , intracellular pathogens exists in two forms Elementary body - metabolically inactive- Reticulate body - larger replicative form ,formed once EB recognised it replicate, then reorganised to EB that spread further. there are three types

C.Pneumoniae : spread by droplet and cause pulmonary pneumonia , pharyngitis and extra pulmonary myocarditis and meningocephalitis

C.Pasittaci : airborne inhalation of infected dropping of birds .. cause acute flu like symp, Atypical pneumonia .. complications are rare but severe , respiratory failure ,hepatitis , endocarditis , encephalitis life threatening in pregnancy

diagnosis : PCR , NAAT serology for IgG and cell culture , treatment : tetracycline and macrolide

C.Trachomatis

Respiratory Tract

Genitals

Eyes

treatment :tetracycline and macrolide , should treat the mother and her partner

inclusion conjunctivitis : D-K , acquired during birth , in adult it cause scarring and blindness , clinical presentation ; inflammation , discharge and swelling of eyelids diagnosed by conjunctival scraping , NAAT and antigen detection

trachoma : A-C , diagnosed clinically , treatment : SAFE

neonatal pneumonia D-K

LGV

STI

D-K .. diagnosis by NAAT , PCR , swap ,, treatment : macrolide and doxycycline chack for other causes of STI

Males

Females

genital ulcer , lymphadenopathy (buboes)

Diagnosis : NAAT of aspirate ,serology

treatment : aspirate buboes , doxycycline

PID

complications during pregnancy

cervicitis but majority are asymptomatic

acute epididymis

proctitis

urethritis with dysuria