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Staphylococci (S.Aureus (infections (toxin mediated infections (TSST-…

- - - - protein A thats bind to IgG to prevent phagocytosis
      - alpha heamolysin bind to platelets and monocytes
      - coagulase
      - leukocidens ,, staphylokinase , hyaluridinase ( spread )
    - - Exfoliative
      - superantigen : TSST and Enterotoxin
  - - - TSST- toxin 1 : massive cytokines release cause pyrexia hypotension , rash with desquamation renal failure and CNS treated with rapid iv antibiotics and resuscitation laboratory FBC , lactate ,U+E, culture and swap
      - exfoliative : scalded skin syndrome .. localised blister or generalised exfoliation .. rehydration ,antibiotics and wound care
      - Enterotoxin: food poisoning and gastroenteritis - no antibiotic use - rehydration only
  - - - history and clinical examination
        
        skin
        
        abscess, SS
        
        Musculoskeletal
      - general investigation Blood , Radiology ,ECHO and pus swap