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Inflammation (5 classic signs (Redness/ erythema (usually easily visible…

- - - - microscopic.... hypermia resulting from dilation of microcirculation
  - - - transudate escapes into tissue, fluid collects in fibrous CT ; localized enlargement
  - - - microscopic...... pressure on the nerves by exudate formation in the tissues
  - - - microscopic....... events associate with swelling and pain
- - - - formation of granulomas= microscopic grouping of macrophages. Usually surrounded by lymphocytes and occasionally plasma cells.
      - cells group together and become multinucleated giant cells
      - ex. Turburculosis
- - - - Kinin System
        
        bradykinin
        
        promote pain
        
        activated by substances in the plasma and injured tissue
        
        increased permiablilty
        
        increased dilation
      - Clotting Mechanism
        
        Stops bleeding
        
        forms fibrinous meshwork at site of injury
        
        protects adjacent tissue through containment
        
        activates Kinin system
        
        dilation
      - Complement System
        
        Domino effect of plasma proteins
        
        function during inflammation and immunity response
        
        Mast cells
        
        release granules from cytoplasm
        
        contains histamine
        
        located in large #s in connective tissue of skin and mucosa