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Genetic evidence for high altitude adaption in Tibet (Distinct…
Genetic evidence for high altitude adaption in Tibet
Distinct physiological traits
Lack hypoxic pulmonary vascoconstriction
Low arterial oxygen concentration
Increased resting ventilation
Decreased incidence of low birth weight
Decreased hemoglobin (Hb) concentration
2 intersecting criteria for genes adapting
Priori candidates for adaption chosen for function
Positive selection in regions of genome
Gene Ontology Project
Merged list with those in Panther-defined Pathway to create an intersecting list
resulted in 247 functional candidate gene loci
alleles subject to positive selection in 31 Tibets
genes increase in frequency
Strong significance better Hb concentration and haplotype variation at 2 genes
PPARA
EGLN1
positive selection found on many genes
Some loci appear in intersection of functional candidate list and section by chance
statistical analysis showed significant difference
inter-individual genetic variation is visible and defined as 3 SNP alleles with the highest IHS value
:
XP-EHH and iHS values
Genome-wide SNP genotypes identified
Dependent on age and sex, study made correlation values for