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Elizabethkingia species** (2007重新分類 (E.menigoseptica, E.miricola, E…

- - - - Quinolone resistance
        
        Alterations in target enzymes-QRDR
        
        Levofloxacin / Ciprofloxacin
        
        phenomenon
        
        Recent reference
        
        QRDR，gyrA ParC
        
        antimicrobial susceptibilty
        
        susceptible
        resistant
        intermediate
        
        E.spp
        
        DNA gyrase, subunit A,(type II topoisomerase)
        
        6 more items...
        
        ParC(DNA topoisomerase IV subunit A)
        
        2 more items...
        
        ParE DNA topoisomerase subunit B
        
        1 more item...
        
        Plasmid-mediated quinolone resistance
        
        Altered drug permeation-PUMP
- - - - phenomenon
        
        E.spp
        
        ParE DNA topoisomerase subunit B
        
        ParE(DNA topoisomerase IV subunit B)
        
        we found one change in the amino acid sequence of GyrB of strain 197 (Ser-494 to Thr), and a Gln substitution was observed in ParE Pro-424 of strain 112.
        
        Novel mutations were found at five different codons and comprised Glu453-Gly His461-Tyr), Ala498-Thr , Val512-Gly, and Ser518-Cys.
        
        ParC(DNA topoisomerase IV subunit A)
        
        初步發現，其ParC gene no mutation in QRDR region such as AA site 78 80 84 #
        
        合成Primer(已完成)，共有二組。一組for E.anohpelis and e.miricola，一組for E.menigoseptica 找不到更conserved sequence
        
        DNA gyrase, subunit A,(type II topoisomerase)
        
        gyrB
        
        DNA gyrase, subunit B (type II topoisomerase)
        
        AA Asp426Asn Lys447Glu
        
        這些抗藥菌株基因分型的結果
        
        合成Primer(已完成)
        
        Result analysis<待基龍米克斯定序結果分析>
        
        PCR/Sequcing<請煜瑄完成後續>
        
        Mismatch Amplification Mutation Assays (MAMA) for Rapid Detection of gyrA and parC Mutations
        
        這些抗藥菌株基因分型的結果
        
        合成Primer(已完成)
        
        Result analysis<待基龍米克斯定序結果分析>
        
        PCR/Sequcing<請煜瑄完成後續>
        
        antimicrobial susceptibilty
        
        susceptible
        resistant
        intermediate
        
        Recent reference
        
        QRDR，gyrA ParC