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Joint Diseases (Osteoarthritis- Wear, tear + repair (Management: Optimise…
Joint Diseases
Osteoarthritis- Wear, tear + repair
Less inflammation, worse on activity
Site: DIP, PIP, CMC, axial skeleton, weight-bearing joints
RF- weight, age, oestrogen, job, previous Hx
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Pain: cytokines, prostaglandins, synovitis,
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NSAIDs
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Non-selective: Aspirin, ibuprofen, naproxen
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Gout 'Recurrent attacks of acute, painful, monoarticular inflammation
Purine metabolism
Adenosine deaminase, nucleoside phos, xanthine deoxidase
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Pathophysiology
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Triggers for attacks
Trauma, dehydration, alcohol, meds, weight loss. Night and morning.
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RFs
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Metabolic syndrome (obesity, dyslipidaemia, hypertension, T2DM)
hyperuricaemia, OH, obesity, diuretics, aspirin. ^purine diet (meat and seafood)
Dx
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Tx: NSAIDs, allopurinol, diet mods
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Rheumatoid Arthritis
Pathophys:
Inhibiting cytokines: TGF-β, IL-4,10
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Activating cytokines: TNF-α,β, IL-1,8,2,6
S/S
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Chronic symmetrical, inflammatory, deforming polyarthritis
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Early Dx + Tx
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DMARDS
Methotrexate- Reduce activity and number immune cells, Chloroquinine- Antigen presentation.
Sulfasalazine: Prodrug, unclear MoA. Triple therapy
JAK inhibitors
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SAIDs:
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Nuclear receptor target, Reduce COX and cytokines
Cushing's: Ocular pressure, cataracts, OsteoP.