Blood

Distribution

Transports nutrients from digestive tract to body

Moves metabolic waste from cells to lungs for removal

Transports oxygen from lungs to body cells

Transfers hormones in endocrine system to target organs

Regulation

Maintains normal blood pH

Regulates body temperature

Maintains blood volume

Protection

Prevents infection by transporting immune elements

Prevents blood loss by transporting clotting factors

Blood consists of two parts:

Formed elements (leukocytes, erythrocytes, platelets)

Plasma

The liquid portion of our blood when it has not coagulated

Uncoagulated blood is used to measure erythrocytes and hemoglobin

92% water and 7% is protein (albumins, globulins, and fibrinogen), 1% electrolytes, gases such as oxygen, vitamins and wastes

Erythrocytes (RBC)

Production begins in red bone marrow and starts from a myeloid stem cell.

Erythrocytes cannot survive more than 120 days in the bloodstream.

Function: pick up oxygen from lungs and release it into the tissues of the body.

Leukocytes (WBC)

Can move out of bloodstream into surrounding tissue through process called emigration.

Two main categories- granulocytes, agranulocytes

Helps fight off infections by removing debris, toxins, and infections agents.

Platelets

Function: to aid in blood clotting

Only live for 10 days

Hemostasis

The process of forming a blood clot (coagulation) is needed in order to prevent continued blood loss from damaged tissues or vessels.

Platelets start coagulation, forming a platelet plug at the area of damage

The cessation of bleeding is hemostasis

Steps To Blood Clotting

Vascular Spasm- Smooth muscle drastically contracts near the site of injury so the blood flow to the area will decrease

Platelet Plug Formation- Platelets begin to adhere to the collagen fibers and endothelial lining of the ruptured vessel. As platelets stick together they form the platelet plug.

Injury- A break in a blood vessel resulting in blood flowing out of the body

Coagulation

Cascade leads to activation of prothrombin. When activated at injury site it becomes thrombin.

Thrombin converts fibrinogen to final fibrin clot. Fibrin is a thread like protein that forms a mesh and prevents anything from going through a damage vessel.

Blood Groups

B- antigen B

AB- antigens A & B

A- antigen A

O- zero A or B antigens

Rh

When someone has their blood typed they will receive their Rh result which is either positive or negative.

Erythropoietin- hormone produced in kidneys that stimulate the hemocytoblasts to divide into erythroblasts, then developing into erythrocytes

Thrombopoietin- hormone produced by liver and kidneys that stimulate hemocytoblasts to develop into megakaryocytes

Megakaryocytes break off pieces into the bloodstream, which are platelets.

Hematopoiesis- the formation of blood cells and platelets, which form in the bone marrow. Can become 2 types of blood cells

Myeloid stem cells- platelets, erythrocytes, and 4 of the leukocytes come from this branch

Lymphoid stem cells- The lymphocyte and 1 of the 5 types of leukocytes come from this branch