Blood
Distribution
Transports nutrients from digestive tract to body
Moves metabolic waste from cells to lungs for removal
Transports oxygen from lungs to body cells
Transfers hormones in endocrine system to target organs
Regulation
Maintains normal blood pH
Regulates body temperature
Maintains blood volume
Protection
Prevents infection by transporting immune elements
Prevents blood loss by transporting clotting factors
Blood consists of two parts:
Formed elements (leukocytes, erythrocytes, platelets)
Plasma
The liquid portion of our blood when it has not coagulated
Uncoagulated blood is used to measure erythrocytes and hemoglobin
92% water and 7% is protein (albumins, globulins, and fibrinogen), 1% electrolytes, gases such as oxygen, vitamins and wastes
Erythrocytes (RBC)
Production begins in red bone marrow and starts from a myeloid stem cell.
Erythrocytes cannot survive more than 120 days in the bloodstream.
Function: pick up oxygen from lungs and release it into the tissues of the body.
Leukocytes (WBC)
Can move out of bloodstream into surrounding tissue through process called emigration.
Two main categories- granulocytes, agranulocytes
Helps fight off infections by removing debris, toxins, and infections agents.
Platelets
Function: to aid in blood clotting
Only live for 10 days
Hemostasis
The process of forming a blood clot (coagulation) is needed in order to prevent continued blood loss from damaged tissues or vessels.
Platelets start coagulation, forming a platelet plug at the area of damage
The cessation of bleeding is hemostasis
Steps To Blood Clotting
Vascular Spasm- Smooth muscle drastically contracts near the site of injury so the blood flow to the area will decrease
Platelet Plug Formation- Platelets begin to adhere to the collagen fibers and endothelial lining of the ruptured vessel. As platelets stick together they form the platelet plug.
Injury- A break in a blood vessel resulting in blood flowing out of the body
Coagulation
Cascade leads to activation of prothrombin. When activated at injury site it becomes thrombin.
Thrombin converts fibrinogen to final fibrin clot. Fibrin is a thread like protein that forms a mesh and prevents anything from going through a damage vessel.
Blood Groups
B- antigen B
AB- antigens A & B
A- antigen A
O- zero A or B antigens
Rh
When someone has their blood typed they will receive their Rh result which is either positive or negative.
Erythropoietin- hormone produced in kidneys that stimulate the hemocytoblasts to divide into erythroblasts, then developing into erythrocytes
Thrombopoietin- hormone produced by liver and kidneys that stimulate hemocytoblasts to develop into megakaryocytes
Megakaryocytes break off pieces into the bloodstream, which are platelets.
Hematopoiesis- the formation of blood cells and platelets, which form in the bone marrow. Can become 2 types of blood cells
Myeloid stem cells- platelets, erythrocytes, and 4 of the leukocytes come from this branch
Lymphoid stem cells- The lymphocyte and 1 of the 5 types of leukocytes come from this branch