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Huntington disease (Neuropsychiatric (Psychoses (psychoses), Amxiety,…
Huntington disease
Neuropsychiatric
Amxiety
Apathy
Depresiion
Agitation
Compulsive behaivior
Disinhibition
Psychoses
General facts
CAG repeats
< 36 healthy
36-39 mild symptoms long healthy
40 will develop disease at young age
Autosomal dominant
Rare disease
1200-1500 PT in NL
60 new people in NL every year
No dis4ease instight
The brain
later stage
Global atrophy
Early stages
degeneration of Striatum
dysfunction fronto-stratial circuits
Changes in dopaminec neurotransmitter system
Symptoms
Cognitive impairments
Psychomotor speed
Executive functioning
Mild until later stages
Attention
Languauge
Memory
social recognition
Motor symptoms
Dystonia
Bradykinesia
Rigidity
Dyskenesias
Chorea
Hypokinesia
Dysarthria