Boala Crohn:inflam transmurala-traveresaza,orice part a tract gastr,ileita,colita, ileocolita BC,aprox 1,1 mil cazuri,50% interventie chir 2/3pac.BC: inflam neuniforma, afect cav bucala pana la anus, fistule, sticturi, manif extraint: spondilita anchil,atralgii, pioderma, psoriazis,, schlerita, uveita,irita,risc mai mare la fumatori,risc de cc