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Antibodies + Cytokines (Immunoglobulins (IgM (Found in blood as cannot…
Antibodies + Cytokines
DEFINITIONS
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Immunoglobulin = A glycoprotein that is bound to B cells as part of the B cell antigen receptor. 5 types: IgG, IgM, IgE, IgA, IgD
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Structure
Fc region binds to complement, Fc receptors on phagocytes and natural killer cells
2 heavy chains, two light chains
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Immunoglobulins
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IgA
Predominant immunoglobulin in mucous secretions i.e. saliva, milk
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Actions
Increases opsonisation - antigen becomes coated with complement so it can be more readily engulfed by phagocytes
Activates complement = IgG, IgM using Fc receptors that convert inactive complement to active complement
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Neutralises toxin by binding to it = IgG, IgA
Cytokines
Features: short half life, rapid degradation
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