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Antidepressants (MAO (A (irreversible (hydarzide: isocarboxazid phenelzine…
Antidepressants
MAO
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Drug int: TCA-->hyperthermia-->seizure; SSRI: same; sympathomimetics + analgesic opiods: hypertensive crises; buspirone: incr BP;
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TCAs
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decr seizure threshold, block vagus,
SSRI
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downreg Ser Rs, decr presynp 5HT 7, D, 1A
Heterocyclics
gen 2
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Bupropion: DA reuptake inhib, also norepi
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antipsychosis
DA Rs
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2,3,4: decr cAMP; excite postsynap; inhib presynap
drugs
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bipolar drugs
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newer: carbamazepine, clonazepam, olanzapine, valproic acid