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OPIATES (SIDE EFFECTS (NARCOTIC EFFECTS AND ADDICTION (INCREASE TOLERANCE…
OPIATES
SIDE EFFECTS
CONSTIPATION
SUPPRESSION OF COUGH REFLEX
CONSTRICTION OF PUPIL IN EYE
NARCOTIC EFFECTS AND ADDICTION
EUPHORIA INDUCED BY HEROIN CREATES DEPENDENCE
USERS CANNOT FUNCTION WITHOUT NARCOTIC (WITHDRAWAL EFFECTS)
INCREASE TOLERANCE TO DRUG
HIGHER DOSES OF NARCOTIC NEEDED
USERS CAN PICK UP HIV THROUGH NEEDLE INFECTION
METHADONE TREATMENT USED TO TREAT ADDICTION
ACTION
OPIATES BIND TO OPIATE RECEPTORS
PREVENTS TRANSMISSION OF PAIN SIGNAL BETWEEN BRAIN CELLS
ENTERS THE BRAIN THROUGH THE BLOOD-BRAIN BARRIER
OPIATES ARE NON POLAR AND LIPID SOLUBLE
DERIVATIVES
CODEINE
COUGH TREATMENT
MANAGEMENT OF SHORT TERM DIARRHOEA
PRODUCED BY CONVERTING -OJ GROUP IN MORPHINE INTO METHYL ETHER (METHYLATION)
CAUSES SIGNIFICANT DROP IN BINDING AT OPIOD RECEPTOR
MORPHINE
SEVER PAIN MANAGEMENT (EX:CANCER)
CAN LEAD TO DEPENDENCY
DIAMORPHINE (HEROIN)
RELIEF OF SEVERE PAIN
PRODUCE EUPHORIC EFFECT
DEPENDENCE LEADS TO WITHDRAWAL EFFECTS
PRODUCED FROM ESTERIFICATION REACTION OF MORPHINE WITH ETHANOIC ACID
INCREASED SOLUBILITY WHICH CAUSES FASTER ACTING TIME
BROKEN DOWN BY ESTERASE IN THE BRAIN
PAIN MANAGEMENT LADDER
USE MILD ANALGESIC
ADD A WEAK OPIOD
IN SEVERE, INTRACTABLE PAIN, USE STRONG OPIODS