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DRUG (Sympathoplegics (B-blockers
olol
non-selective - B1, B2…
DRUG
Sympathoplegics
a1-blockers
sin
- block receptor in vascular smooth muscle, dilate
- baroreceptor, higher HR
- relax bladder & prostate
-
-
B-blockers
olol
- non-selective - B1, B2 (propanolol)
- cardio selective - B1
- lower HR and contraction
- decrease renin release
- Lower SVR
Side effect
- Bronchiospasm
- Bradyarrythmias
CNS depression
-
Vasodilators
Nitrates
Nitroprusside, ISDN
- release NO, higher cGMP, SM relax
- vasodilation
- dilate coronary artery
- intensive 1st pass metabolism
Adverse
- Postural Hypotension
- Throbbing headache
- tachycardia
-
Others
Hydralazine
- direct-acting smooth muscle relaxant causing vasodilation
- oral or IV
Adverse
- Lupus erythematosus syndrome
- perpheral neuropathy
Ca blockers
pine
- act on L type voltage Ca channel
- block Ca2+ entry to SMC
- inhibit slow Ca current in SA & AV node
- (-) ionotropic effect
- lower PVR & HR
- lower coronary vascular resistance
- good oral
Side effect
- flushing
- headache
- brachycardia
- ankleswelling
- constipation
- gingival hyperplasia
-
RAS inhibitors
ARBs
tan
- inhibit action of A II at A II sub type 1 receptor
- vasodilate, lower SNS activity
- no effect on bradykinin
- longer half life
-
-
Renin inhibitor
Aliskiren
- inhibit renin
- poor oral absorption
-
-
ACE inhibitors
pril
- inhibit formation of A II , inhibit degradation of bradykinin
- block effects of A II on sympathetic nerve release
- decrease aldosterone secretion , reduce salt retention
Side Effect
- dry cough
angioedema
hyperK
Hypotension
Acute renal failure
-
Diuretics
zide
- lower BP, depleting body Na stores, lower resistance
- reduce BV-lower CO
- vasodilate
Adverse
- hypovolumiia
- electrolyte imbalance
- Hyperglycemia & hyperuricemia (thia)
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