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Introduction to the Pharmacology of CNS Drugs (NTs (types ((classic)…
Introduction to the Pharmacology of CNS Drugs
NTs
types
(classic) nonpeptides
aa
neutral: inhibitory
Gly
(more in spinal cord)
GABA
:
A: has muscle relaxant effects
B
: specifically muscle relaxing
(baclofen acts through this)
acidic: Glu, Asp
:
excitatory; in memory, apoptosis
, physiopatho of some CNS functions (like trauma);
Rs: ionotropic: NMDA, AMPA, Kainate; G pr coupled
monoamines
ACh: cognitive, esp memory;
Serotonine: in raphe nuclei; in sleep, appetite and analgesia
DA: 5 subtypes, MAO and COMT important in metabolism
Norepi: Tyr-->DA-->norepi; b Rs more important in CNS, u. inhibitory, propranolol anxiolytic
peptides: no reuptake or specific E systems identified for termination of peptide action; synth in cell body; released when needed, short half life
Best known: Opiods
Lesser known: Substance P, gamma neuropeptide, neurotensin, CCK (b subtype in brain: depression and appetite)
definition: present in higher amounts in synaptic area than other areas (localized); released; must mimic synaptic activity
Rs
ionotropic
Na, K
5HT-3
NMDA
Cl
GABA-A
ACh nicotinic R
G pr coupled
ACh muscarinic R
GABA-B
norepi beta R
all other 5HT Rs
DA Rs