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Diabetic Ketoacidosis (Lab Test Monitoring (Check blood pressure for every…
Diabetic Ketoacidosis
Lab Test Monitoring
Check blood pressure for every routine visit.
- Most patients:
<140/90 mmHg
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Urine albumin/microalbumin levels for once a year in patients with type 1 diabetes who had diabetes for at least 5 years.
- <30 µg/mg creatinine is normal
- BUN level = 7-20 mg/dl
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Creatinine level and eGFR
for every year.
Blood Glucose by SMBG
Patients using multiple insulin injections or an insulin pump:
- 80 to 130 mg/dL (fasting or before meals)
- <180 mg/dL (1 to 2 hours after start of meal)
HbA1c Test by checking HbA1c level.
- Targeted level: Patients who are recently diagnosed, otherwise healthy, or not at significant risk for hypoglycemia: <6.5%
Blood test for ketone by blood glucose meters.
- Less than 0.6 = normal.
- 0.6 - 1.0 = slightly high
- 1.0 - 3.0 = moderately high
- Higher than 3.0 = very high
Acid/base status.
- pH =7.35-7.45
- PaCO₂ = 38-112 mm Hg
- PaO₂= 75-100 mm Hg
- HCO3 = 25-28 mEq/L
- O₂ = 97-100%
Risk Factors
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Infection or other illnesses ( eg : stroke, pancreatitis, MI )
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Type of insulin
Rapid Acting
Usually taken before a meal to cover the blood glucose elevation from eating. This type of insulin is used with longer-acting insulin.
Short Acting
Usually taken about 30 minutes before a meal to cover the blood glucose elevation from eating. This type of insulin is used with longer-acting insulin.
Intermediate Acting
Covers the blood glucose elevations when rapid-acting insulins stop working. This type of insulin is often combined with rapid- or short-acting insulin and is usually taken twice a day.
Long Acting
This type of insulin is often combined, when needed, with rapid- or short-acting insulin. It lowers blood glucose levels when rapid-acting insulin stop working. It is taken once or twice a day.
Pharmacotherapy
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IV Fluid Resuscitation
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Then, change IV to 0.45% NaCl with 20-40 mEq KCl/L
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Goal of Therapy
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:star: To correct dehydration, correct acidosis and reverse ketosis
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Precipitating FactorsHow DM type 1 to DKA?
- DKA, primarily a type 1 diabetes complication
- DKA happens when signal insulin is low that
i) glucose can't go into cells to be used as a fuel
sources
ii) the liver makes a huge amount of glucose
iii) fat is broken down to rapidly for the body to process