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Theme12. NEUROTRANSMITTER SYSTEMS IN THE BRAIN( (NEUROTRANSMITTER…
Theme12. NEUROTRANSMITTER SYSTEMS IN THE BRAIN(
NEUROTRANSMITTER
hemicalsignalsreleasedfrompresynapticnerveterminalsintothesynapticcleft.
2.- released in response topresynapticdepolarization,
3.- Specific receptors for the substance must be present on thepostsynapticcell.
1.- present within thepresynapticneuron
PACKAGING NEUROTRANSMITTERS
A)Smallclear-corevesicles
B)Largedense-corevesicles
NEUROTRANSMITTER RELEASE
storedattheterminaloftheneuronin:
Activezones
Vicinityofactivezones
Excitatory(EAA)
Glutamate
Aspartate, Cysteine& Homocysteine
Inhibitory(IAA)
GABA
Glycine
Taurine
The Axonal transport
organelleandmoleculetransportationalongthenervefiber
Fastaxonaltransport(bidirectional)
Slowaxonaltransport(anterograde)
NEUROPEPTIDES: OPPORTUNITIES FOR DRUG DISCOVERY
Termination of their action by the action of
endopetidases
Released under burts of high firing frequency
mainly outside the sinapsis,
Functions: analgesia; food inatke, learning &
memory, social behavior, reproduction, anxiety, etc.
Neuropeptides are produecd in the cell body and sometimes packaged alongwith clasic NTs
Their receptors are only metabotropic
Metabotropic receptors
(A)G-proteindirectcoupling
(B)G-protein-inducedsignalingcascade