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Muscarinic Antagonist (long term controllers/preventers (long term control…

- - - - life saving
    - - by inducing annexin-1 (lipocortin-1) they could inhibit the production of leukotrienes and PAF)
        
        inhibits generation of vasodilators, PGE2, PGI2 (inhibits COX-2)
        
        up regulates B2 adrenoreceptors
        
        decrease microvascular permeability
    - - reduce production of cytokines, IL-3 that regulates mast cell production