Please enable JavaScript.

Coggle requires JavaScript to display documents.

Neurobiology of sleep (Role of orexin in stability of sleep & waking…

- - - - DORSAL
        from cholinergic neurons in the pedunculopontine and laterodorsal tegmental nuclei -> innervating the thalamus (the relay nuclei & the reticular nucleus)
        
        reticular nucleus has GABAergic neurons that project back into the thalamus and inhibit it
        
        arousal system inhibits the reticular nucleus, thus opening the way for thalamocortical transmission
      - VENTRAL
        from monoaminergic neurons (includes the NE locus coeruleus, 5HT dorsal and median raphe nuclei, Glu parabrachial nucleus, DA periaqueductal gray matter, and HA TMN)
        
        Neurons in each of these sites send axons through the lateral hypothalamus to the basal forebrain and cerebral cortex
        
        peptidergic (ie, orexin, or hypocretin) and glutamatergic neurons in the lateral hypothalamus and cholinergic and GABA-ergic neurons in the basal forebrain that project to the cerebral cortex contribute