Objective 2 "Dairy product intake and lean mass and cognitive…
"Dairy product intake and lean mass and cognitive function"
choice reaction time
first two plates stroop?
💩Nancy Presse article - but according to Tuokko in CLSA they use Stroop to evaluate executive function only...
Question: Frequency alcohol consumption past 12 months
Alcoholism or high consumption =
vitamin B1 (thiamin) deficiency
Sex difference: women will develop cognitive impairment associated with it quicker vs men (more sensitive)
Can lead to Wernicke's encephalopathy (short-lived) and Korsakoff's psychosis (long-lasting)
persistent learning and memory problems
no diff according to study by Tuokko
It could hide the relationship as those with higher fat mass (and BMI) have higher lean mass (carry more weight) and may have greater chronic diseases = lower cognitive function
Center for Epidemiological Studies Short Depression Scale (CES-D 10)
happy, lonely, depressed, could not get going, everything is an effort, trouble concentrating, hopeful about future
90% of patients with depression suffer with cognitive impairments (memory and concentration)
Hypertention, T2DM, heart disease
adjust for use of specific medication
adjust for overal # of medications
adjust for BP (not going to be consistent with other diseases)
Physical activity level
Physical Activity Scale for the Elderly (PASE) - Washburn
light, moderate, strenuous sports
muscle strength and endurance
housework, repairs, gardening, yard care
Those with higher physical activity may have higher lean mass and cognitive function (clearly associated with better cognitive performance and brain volume) (Erickson et al.)
💩 Social participation
💩 Adjust for language
Inflated weight available in the dataset for number of person that could be randomly selected per provinces
Diet quality or dietary pattern
Parrott et al. J Nutr - 2013
Prudent vs Western pattern
Used PCA --> identified 3 patterns, retained 2
Classified NuAge participants into these and did analyses accordingly.
-No details on coefficients for PCA
*using short diet questionnaire but a pattern is not quality... unless I see that one specific pattern is associated with cognitive function than I will want to adjust for it and see if regardless of pattern, dairy product consumption is associated with cognition.
Robinson - J Nutr Health Aging - 2017
PCA to determine dietary pattern look for healthy one that appears to follow guidelines
find coefficient (some food items will have negative others positive correlation with that specific dietary pattern.
Do not include milk products as part of this pattern
Food items frequencies were standardized (I don't think I have to do that because they are frequencies (already standardized under consumptions per day)
Coefficient for each food multiplied by food frequency
Add these to create one score for each subject
Emails: cannot evaluate global diet via SDQ. Not possible to calculate diet quality index.
Milk product intake
🚨 Extrapolation of milk product portion sizes from NuAge or from CCHS
échange de courriels. Options limités. Les portions typiquement consommées n'ont pas été calculées, seulement en terme de # de portions de GAC.
Use only frequencies
Mediation of ALM and Milk product intake