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Objective 2 "Dairy product intake and lean mass and cognitive…

- - - - choice reaction time
      - first two plates stroop?
        
        💩Nancy Presse article - but according to Tuokko in CLSA they use Stroop to evaluate executive function only...
    - - REY
    - - MAT
      - stroop
        
        third plate
- - - - Question: Frequency alcohol consumption past 12 months
        
        Alcoholism or high consumption = vitamin B1 (thiamin) deficiency
        
        Sex difference: women will develop cognitive impairment associated with it quicker vs men (more sensitive)
        
        Can lead to Wernicke's encephalopathy (short-lived) and Korsakoff's psychosis (long-lasting)
        
        persistent learning and memory problems
    - - stratify?
        
        no diff according to study by Tuokko
    - - DXA
      - Why?
        
        It could hide the relationship as those with higher fat mass (and BMI) have higher lean mass (carry more weight) and may have greater chronic diseases = lower cognitive function
    - - Center for Epidemiological Studies Short Depression Scale (CES-D 10)
        
        happy, lonely, depressed, could not get going, everything is an effort, trouble concentrating, hopeful about future
      - Why?
        
        90% of patients with depression suffer with cognitive impairments (memory and concentration)
    - - adjust for use of specific medication
        
        adjust for overal # of medications
      - adjust for BP (not going to be consistent with other diseases)
    - - Physical Activity Scale for the Elderly (PASE) - Washburn
        
        Sitting activities
        
        walking
        
        light, moderate, strenuous sports
        
        muscle strength and endurance
        
        housework, repairs, gardening, yard care
      - Why?
        
        Those with higher physical activity may have higher lean mass and cognitive function (clearly associated with better cognitive performance and brain volume) (Erickson et al.)
    - - Parrott et al. J Nutr - 2013
        
        Prudent vs Western pattern
        
        Used PCA --> identified 3 patterns, retained 2
        
        Classified NuAge participants into these and did analyses accordingly.
        -No details on coefficients for PCA
        
        *using short diet questionnaire but a pattern is not quality... unless I see that one specific pattern is associated with cognitive function than I will want to adjust for it and see if regardless of pattern, dairy product consumption is associated with cognition.
      - Robinson - J Nutr Health Aging - 2017
        
        PCA to determine dietary pattern look for healthy one that appears to follow guidelines
        
        find coefficient (some food items will have negative others positive correlation with that specific dietary pattern.
        
        Do not include milk products as part of this pattern
        
        Food items frequencies were standardized (I don't think I have to do that because they are frequencies (already standardized under consumptions per day)
        
        Coefficient for each food multiplied by food frequency
        
        Add these to create one score for each subject
      - Bryna Shatenstein
        
        Emails: cannot evaluate global diet via SDQ. Not possible to calculate diet quality index.
- - - - Isabelle Massarelli
        
        échange de courriels. Options limités. Les portions typiquement consommées n'ont pas été calculées, seulement en terme de # de portions de GAC.