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Systemic Lupus Erythematosus (Manifestations (Skin (Malar, Discoid rash,…
Systemic Lupus Erythematosus
Causes
Genetic
Environmental
Hormonal
Loss of tolerance
Autoantibody production by B lymphocytes
Cytotoxic T lymphocyte activation
Acquired sensitivity to auto-antigens
Manifestations
Skin
Malar
Discoid rash
Photosensitivity
Ulcers
Kidney
Glomerulonephritis
Musculoskeletal system
Arthritis
Joint inflammation
Joint pain
Cardiopulmonary
Pleural effusion
Pericardial effusion
Pleuritis
Pericarditis
Neurologic
Seizures
Psychosis
Hematologic effects
Hemolytic anemia
Leukopenia
Thromboctyopenia
Type III hypersensitivity reaction
Persistent antigen-promoting complex deposition
Inflammation
Treatment
Anti-inflammatory
NSAIDs
Salicylates
Glucocorticoids
Immunosuppression
Hydroxychloroquine
Azathioprine
Cyclophosphamide
Methotrexate
Permanent organ damage
Immune complex formation in tissues/circulation