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module 5 Pharmakokinetics (dosing (loading dose/priming dose (reach…
module 5 Pharmakokinetics
bioavailability:
AUC on plasma conc vs time graph
absolute bioavailability : compares AUC of administration through route x vs that of IV for same drug
relative bioavailability:
allows more practical comparison by multiplying AUCa/AUCb x DOSEb/DOSEa
bioequivalence:
no diff in rate and extent of absorption of the therapeutic/active ingredient
drug accumulation
one compartment model vs two compartment model
dosing
dose not affect half life
route of administration
oral
IV: more immediate action (higher initial conc)
multiple dosing
maintenance state: drug swing = concentration at peak - trough
loading dose/priming dose
reach maintenance quickly
not for drugs w/ low therapeutic index
follow w/ graded continuous infusion or repeated doses
drug elimination
usually first order kinetics (constant %)
elimination rate constant k = 0.69/half-life
half life: time it takes to dec drug conc by 1/2
unique for each drug
constant
zero order kinetics when elimination path saturated
