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chapter 16 and 17 (Synthesizing a New DNA Strand (Primase can start an RNA…
chapter 16 and 17
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Antiparallel Elongation
Along one template strand of DNA, the DNA polymerase synthesizes a leading strand continuously, moving toward the replication fork
To elongate the other new strand, called the lagging strand, DNA polymerase must work in the direction away from the replication fork
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The lagging strand is synthesized as a series of segments called Okazaki fragments, which are joined together by DNA ligase
DNA polymerases add nucleotides only to the free 3′ end of a growing strand; therefore, a new DNA strand can elongate only in the 5′ to 3′ direction
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origins of replication
At the end of each replication bubble is a replication fork, a Y-shaped region where new DNA strands are elongating
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Replication begins at particular sites called origins of replication, where the two DNA strands are separated, opening up a replication “bubble”
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Topoisomerase relieves the strain of twisting of the double helix by breaking, swiveling, and rejoining DNA strands
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