Please enable JavaScript.
Coggle requires JavaScript to display documents.
Pharmacokinetics - Module 5 (Bioavailability (Therapeutic equivalence…
Pharmacokinetics - Module 5
Accumulation
Distribution models
One-compartment
Two-compartment
Elimination
Zero order
Constant amount of drug lost per unit time
Alcohol
Salicylate
Phenytoin
First order
Constant percentage of drug lost per unit time
Bioavailability
Absolute
Compared to IV administration of the same drug
Relative
Compared to a different preparation of the drug
Bioequivalence
No significant different in the the rate and extent of absorption of the therapeutic ingredient
Therapeutic equivalence
Substitute will produce the same clinical effect and safety profile as the prescribed product
Same active ingredients
Same dosage form
Same route of administration and strength
Dosing
Multiple dosing
Dosing interval
Drug swing
Loading / Priming dose
Long half life
contraindicated for drugs with low therapeutic index
Followed by repeated or graded continuous infusion