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Interleukin-1B (IL-B) (BIOSYNTHESIS (Production and release of IL-1beta…
Interleukin-1B (IL-B)
INTRODUCTION
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IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.
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MECHANISM OF ACTION
using the IL-1 receptor antagonist, which inhibits cell death caused by ischemia, brain injury, or excitotoxins
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During a sudden insult of ischaemic stroke, neurons rapidly die but additional cellular loss can occur hours and days thereafter, with limited repair.
The brain responds by activating resident cells such as microglia and astrocytes and producing pro-inflammatory mediators that attract various types of immune cells.
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FUNCTIONS
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involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.
BIOSYNTHESIS
Production and release of IL-1beta are stimulated by either pathogen-associated molecular pattern molecules (PAMPs) or damage-associated molecular pattern molecules (DAMPs) and involve several steps.
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3) fusion of multivesicular bodies with the plasma membrane and subsequent release of IL-1beta-containing exosomes
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PATHOPHYSIOLOGY
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Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane
Interleukin (IL)-1β and tumor necrosis factor (TNF) control the degeneration of articular cartilage matrix, which makes them prime targets for therapeutic strategies
