Please enable JavaScript.
Coggle requires JavaScript to display documents.
Metimazole (Farmakokinetik (Distribusi (half life 5-6 hrs., volume 40L),…
Metimazole
Farmakokinetik
Absorbsi
rapid with oral bioavailability of 93%
Ekskresi
urine
Metabolisme
Hepatic primarily
Distribusi
half life 5-6 hrs.
volume 40L
Indikasi
Hyperthyroid
Goiter
Grave's disease
Psoriasis
Farmakodinamik
Efek
Inhibits thyroid hormone synthesis
MoA
inhibits thyroid peroxidase
Inhibits coupling
AE
Skin rash
agranulocytosis
GI upset
nausea
headache
Kontraindikasi
liver disease
agranulocytosis
pregnancy
Bentuk sediaan
Tablet 5mg
Dosis
1-2x daily