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Drug accumulation, elimination, dosing (maintenance/plateau state: point…
Drug accumulation, elimination, dosing
bioavailability
amount of drug that actually reaches the systemic circulation, protein
bound or unbound
relative measure of drug absorption which describes the amount of drug that is absorbed after administration by route X, often oral administration, compared to amount absorbed after IV administration
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bioequivalence
FDA: “If a drug acts through absorption into the bloodstream, bioequivalent drug products are those that show no significant difference in the rate and extent of absorption of the therapeutic ingredient.”
therapeutically equal drugs: same bioequivalence dosage, active ingredients, route of administration, strength
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zero order kinetics
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drugs that saturate elimination routes disappear from plasma im non-cooncentration dependent process
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maintenance/plateau state: point where peak plasma concentration does not change even with additional administration of drug
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