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Protein Synthesis Inhibitors (TETRACYCLINES (Mechanism of action: enter…
Protein Synthesis Inhibitors
CHLORAMPHENICOL
OXAZOLIDINONES
STREPTOGRAMINS
TETRACYCLINES
Antimicrobial Activity
Broad-spectrum bacteriostatic
Active against gr+ & gr - (aerobic, anaerobes)
Rrickettsiae
Chlamydiae
Mycoplasmas, and L forms
Protozoa (eg, amebas)
Ex
Tigecycline
Active against
Staphylococcus aureus, MRSA, VRSA
Enterococci, including vancomycin-resistant strains
intrinsically resistant: Proteus and P aeruginosa
Mechanism of action: enter microorganisms by
Passive diffusion
Energy-dependent process of active transport
Bind reversibly to the 30S subunit of the ribosome
Block the binding of aminoacyl-tRNA to the acceptor site
Prevents addition of amino acids to the growing peptide
Resistance
Impaired influx
Increased efflux by an active transport protein pump
Ribosome protection
Production of proteins that interfere with tetracycline binding to the ribosome
Enzymatic inactivation
Pharmacokinetics
MACROLIDES
CLINDAMYCIN