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RAS (genes (K-Ras (KRAS4A, KRAS4B), N-Ras, H-Ras, на С конце Ras имеют HVR…

- - - - Rap2
        
        Rab2C
        
        RAb2B
        
        Rab2A
        
        Rap2 inhibits many Ras pathways including Ras-induced Raf activation at the plasma membrane
        
        Rap2 также связывается с Ral GEF, Ral GDS, RGL и RLF
        
        Rap2 is reported to localize mainly in the endoplasmic reticulum (ER)
      - Rap1
        
        Rab1B
        
        Rap1A
        
        Rap1 may actually regulate adherens junctions. Cell-cell junctions are formed evenly around the lateral circumference of cells by homophilic interactions between the extracellular domains of E-cadherin, linked by their intracellular tail to catenins and to the actin cytoskeleton
        
        DOCK4 specifically activates Rap1 and regulates the formation of adherens junctions
        
        activation of Rap1 may then activate inside-to-outside signaling through stimulating actin polymerization, which mediates the further recruitment of E-cadherin from the cytoplasmic or plasma membrane pool and facilitates the formation of mature Ecadherin-based adherens junctions
        
        Rap1 localizes at the Golgi apparatus
      - activated Rap promotes adhesion through integrin activation
        
        function as regulators of integrin mediated cell adhesion and cell spreading