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17_fMRI - Coggle Diagram

- - - - A-priori information (constant for each voxel)
      - composed
        
        column variable (regressor)
        
        row = acquisition
  - - - contrast vector
        
        single regressor significance
        
        logic or
        
        difference
    - - bonferroni
      - FDR
      - small volume correction
      - cluster size correction
  - - - affine transformation
    - - spatial filtering with gaussian kernel
    - - rigid transformation
- - - - Diamagnetica
    - - Paramagnetica (inomogeneità campo <MR Signal)
  - - - HRF
- - - - to evaluate brain activation relative to a specific function
    - - Brain activation in response to different stimuli/conditions
      - Functional connectivity: temporal correlation between spatially remote neurophysiological events
      - Brain activation in response to a stimulus/condition
      - Effective connectivity: the influence one neuronal system exerts over another (causal relationships)
    - - Block design
      - Event related design
  - - - high temporal resolution
- - - - Rehabilitation effects
      - Residual functions evaluation
    - - Evaluation of functional loss
    - - Relationship between white matter damage and gray matter function
      - evaluation brain plasticity
      - Effect of treatments
  - - - Functional connectivity
        
        temporal correlation between spatially remote neurophysiological events
        
        metodi
        
        correlation analyses
        
        Independent Component Analysis (ICA)
      - Effective connectivity
        
        the influence one neuronal system exerts over another (causal relationships)
        
        metodi
        
        Granger Causality,
        
        Dynamic Causal Modeling (DCM)
    - - Brain is activated (at low frequencies) even without any stimulus (resting state)
      - data required in resting condition
      - Default Mode Network
      - Aims of research in Resting State fMRI
        
        􏰁 Validation of a standard analysis method
        
        􏰁 Evaluation of possible additional information provided with respect to task fMRI
        
        􏰁 Help for diagnosis / efficacy of treatments
      - Advantages and limits:
        
        No standard analysis method (-)
        
        Simple experimental protocol (+) 􏰁
    - - widespread technique for FC analysis of a specific network of interest.
      - Pearson's linear correlation between the signal extracted from a specific region of interest (seed) and all the other brain voxels.