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Shigella, Hemolytic uremic syndrome - Coggle Diagram
Shigella
Morphology
rode-shaped
facultative anaerobe
gram-negative
no flagellum --> non-motIle
no spores
non-lactose fermenter
urease & oxidase negative
no hydrogen sulfide gas
Pathogenesis
Shiga-toxin
of S dysenteria
targets to ribosomes --> arest of protein syntesis
cell death
can get into the kedneys -->
protenuria & thrombocytopenia
microangiopathic hemolysis (because of multiple blood clots) -->
anemia
--> ishemia of kedneys --> uremia
targets colonic enterocytes & M-cells
M-cells phagocytoses
macrophages
apoptosis
cytokines: IL1beta
death of epithelial cells --> ulcerations & abscesses
Epidemiology
fecal-oral rout
Symptoms
Dysentery
pain
abdominal & rectal cramping (спазмы)
fever
vomiting
loss of appetite
fecal incontenence (недержание)
water, mucose flaked diarrhea (blood/pus)
in sever cases - tonic-clonic seizures
Diagnosis
fecal sample
PCR testing
Treatment
fluid & electrolytes replenishment
Antibiotics
beta-lactam (penicillins & cephalosporins)
macrolides
quinolons
Hemolytic uremic syndrome
Hemolitic anemia
kidney failure --> uremia
thrombocytopenia