weakness - serious side effects, dizziness, agitation, sleepiness stiff jaw, weight gain, itchy skin, lowered sex drive etc. can lead to tardive dyskinesia (caused by dopamine hypersensitivity, causes involuntary facial movements eg. grimacing, blinking), most serious side effect is NMS (neuroleptic malignant syndrome), which is caused by the dopamine blockage in the hypothalamus, causes high temperature, delirium, coma, can be fatal, this means that antipsychotics can do harm as well as good, patients will avoid taking their meds due to the side effects. mechanism unclear, we do not know why antipsychotics work, dopamine hypothesis is an incomplete explanation, some antipsychotics aren't the best option for ppl to choose