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Bone scan - Coggle Diagram

- - - - Tissue (Blood pool) phase
        
        1-10 mins post-injection
        
        tissue distribution of tracers
        
        enter extracellular phase
        
        infection or inflammation (capillary permeability)
      - Whole body (delay) scan
        
        2-4 hrs post-injection
        
        accumulation of bone seekers
        
        may wait longer for renal incompetent patients
        
        metastatic diseases
        
        osteoblastic activities
      - vascular(first pass) phase
        
        immediate imaging
        
        degree of vascularity associated with disease
        
        bone injury and infection
        
        hypervascularity - acute osteomelitis
        
        hot in all 3 phases
        
        hypovascularity - avascular necrosis
        
        cold in vascular and tissue phases
    - - anterior
      - posterior
- - - - increases tissue uptake
    - - breast cancer: lower limb injection
      - pay special attention on affected side
- - - - • Stress or frank fractures
      - • Physical abuse (nonaccidental trauma)
      - • Postsurgical osseous changes
      - • Loose prosthesis
  - - - • Prostate
      - • Lung
      - • Breast
- - - - • Infarction
      - • Intrinsic vascular lesion
      - • Early aseptic necrosis
    - - • Neuroblastoma
      - • Renal cell carcinoma
      - • Thyroid carcinoma