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Cryptosporidium parvum, image, image, image, image, image, image - Coggle…
Cryptosporidium parvum
INTRODUCTION
E.E Tyzzerin described in 1907
coccidian protozoan parasite
crytosporidiosis
Associated with AIDS in the early 1980s
no safe and effective treatment
MORPHOLOGY
Oocysts
4-5 microns
shed for several weeks after symptoms resolve
infection may result from 10 oocysts
sporulated
they are immediately infectious
4 crescent shaped, naked,non-encysted sporozoites
survive in extreme conditions
Acid fast staining
LIFE CYCLE
invasion of intestinal epithelial cells
Asexual life cycle
Excystation (release of 4 sporozoites)
sexual life cycle
Differentiation of micro & macrogametes
Development of oocysts
Formation of new infectious sporozoites
PATHOGENESIS & CLINICAL MANIFESTATIONS
10-20 liters of watery stool / day
Incubation - 1-14 days
epithelial cells damage
Bile duct infection , chronic diarrhea
Symptomatic respiratory crytosporidiosis
Symtomatic intestinal crytosporidiosis
Malabsorption
MODE OF INFECTION
Fecal-oral
waterborne
food borne
aerosal infection
community (person to person)
LAB DIAGNOSIS
stool concentration technique
Acid fast (oocyst as bright red-blue)
Stool examination
Histopthological
Molecular diagnnosis
Immunofloresecent
TREATMENT
supportive treatment to prevent dehydration
supportive therapy
No effective treatment available
