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Discuss the influence of powder particle size and particle size range on…
Discuss the influence of powder particle size and particle size range on the pharmaceutical processes of mixing, flow, size reduction and compaction.
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Mixing flow
- large size decrases the flow rate, rate of process decreases
Size reduction
- optimum size particles
•produces better mixture formulation
•better distributions of the particles
compaction
increase pressure, increase surface area
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Describe the stability tests that are performed for a prospective drug during preformulation. Include in your discussion the concept and advantages of accelerated stability testing
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