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HAEMOSTATIC DISORDERS, PLATELETS, THROMBOPOIESIS - Coggle Diagram

- - - - Immediate phenomenon
        
        Responsible for cessation of bleeding from microvasculature
        
        3 steps :
        
        platelet adhesion,
        
        platelet granule release and
        
        platelet aggregation
  - - - vessel wall platelets
        
        coagulation factors
    - - vessel wall
        
        platelets inhibitors
        
        fibrinolytic system
    - - To establish a definite
        diagnosis the following
        scheme is followed
        
        Comprehensinve clinical
        evaluation
        
        Screening tests
        
        Specific tests
      - INVESTIGATION OF HAEMOSTATIC FUNCTION
        
        Blood vessel wall : vascular haemostasis
        
        Platelets
        
        Plasma coagulation factors
        
        Fibrinolytic system
        
        Inhibitors of coagulation
        
        coagulation
        cascade
        
        coagulation tests
        
        table
        
        table
  - - - Formation of fibrin plug
        
        Takes several minutes to complete
- - - - 70% in circulation, 30% in spleen
        
        Newly formed platelets spend
        24 – 36 hrs in spleen
        
        Stress,
        
        epinephrine and
        
        exercise
        stimulate thrombopoiesis
- - - - Under control of Thrombopoietin