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POLYCYTHEMIA VERA - Coggle Diagram
POLYCYTHEMIA VERA
INTRODUCTION
Clonal disorder characterized by
- increased production of all myeloid elements
resulting in pancytosis in absence of any recognizable cause
- Primary or idiopathic polycythemia
- is most common of all myeloproliferative disorders
-
- Secondary polycythemia or erythrocytosis :
high altitude, CVS disease,
pulmonary disease with alveolar hypoventilation, heavy smoking, inappropriate increase in erythropoietin
CLINICAL FEATURES
- Disease of late middle life
- and is slightly more common in males
- Headache, vertigo, tinnitus, visual alterations, syncope
- Increased risk of thrombosis
- Increased risk of haemorrhages
- Increased risk of urate stones
LABORATORY FINDINGS
Raised Hb
- above 17.5 g/dl in males and
- 15.5 g/dL in females
- Mild to moderate leucocytosis
- Bone marrow examination reveals erythroid hyperplasia or panhyperplasia
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