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Gram positive bacilli (purple) - Coggle Diagram

- - - - 治疗：
        Rapid treatment,
        antibiotics
        vaccine
      - Encode pXO1 & pXO2 plasmid
        used in bio-terrorism & warfare
        commonly found in animal hides
        Exotoxin composed of 3 separate proteins:
        
        Edema factor (EF)
        
        Protective antigen (PA)
        
        Lethal factor (LF)
    - - Cause food poisoning ;
        2 enterotoxin (exotoxin in GI tract) : heat labile & heat stable
      - 治疗：
        Antibiotic 无效（preformed toxin)
  - - - neurotoxin 导致 food poisoning 死亡（阻止Ach release）
      - 治疗：
        Antitoxin & respiratory assistantance
      - infant botulism
        
        2-3岁不能吃Honey （may contain spore)
      - 总结：entry adult, infant; spread toxin, prevent Ach; paralysis
    - - tetanus 发生在Rusty nail with spores puncture & wound ( anaerobic )
      - Exotoxin: tetanospasmin ( skeletal muscle, spasm痉挛）
      - booster / 10 years (2nd immune response down)
      - 总结：Entry wound ( break in skin); find anaerobic, made exotoxin, muscle contract; then lock jaw, 心脏和呼吸失败
    - - Gas gangrene; in soldiers wound;
      - 治疗：
        Fatal unless 用 O2, antibiotics, remove damage tissue
      - 2 infection:
        wound infection
        clostridial myonecrosis
    - - 引起antibiotic-associated pseudomembranous colitis
      - 过度使用 antibiotic— 摧毁good intestinal flora
      - 释放 2 exotoxins:
        A导致diarrhea
        B导致(cytotoxic ) to colon cells
      - 治疗：
        antibiotics:
        metronidazole , vancomycin (停留在结肠）
      - 总结：
        Entry
        spread-注射broad of antibiotic
        disease-diarrhea & pseudomembranous colitis