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Streptococcus pyogenes - Coggle Diagram
Streptococcus pyogenes
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Virulence factors
M proteins▫Protect microbe from humoral immune surveillance, phagocytosis by polymorphonuclear leukocytes
Binding proteins▫Bind to IgG, IgM, IgA → may interfere with complement activation▫ Protein F: binds to fibronectin → ↑adherence to epithelial surfaces
Cytolysins
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Pyrogenic exotoxins (type A, B, C) Induce fever, act as superantigens → T-cell proliferation → ↑ cytokine production→ promotes shock
Streptokinase: proteolytically converts bound plasminogen to active plasmin → cleavage of fibrin; medically useful as clot-busting drug
Desoders
Toxic diseases
Scarlet fever (intracapillary hemolysis): fever, bright skin rash, sandpaper feel on tongue
Toxic shock syndrome (TSS): Shock, multiorgan failure
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Pyogenic diseases
cellulitis (abscess formation in dermis, subcutaneous fat layers):Erythema, edema, abscess formation
necrotizing fasciitis (progressive destruction of deep soft tissue): fever, painful & purple skin
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Erysiperas (upper dermis, superficial lymphatics): warm, painful & raised lesions
Pharyngitis (fever, painful swallowing, reddish, swollen tonsils, pus on it)
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