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huang - Coggle Diagram
huang
nucleotide excision repair
Damage recognition
Transcription coupled NER
RNA polymerase
Global genomic NER
(DNA-damage binding)DDB2
recruits XPC
XPC-Rad23B
Dual incision
XPG
scaffold
Replication protein A (RPA)
XPA
Repair and ligation
DNA polymerases (δ, ε and/or κ)
DNA ligase I
verify
Transcription factor II Human(TFIIH)
XPB
XPD
DNA damage
UV
cyclobutane pyrimidine dimers(CPD)
benzo[a]pyrene
lung cell
BEAS-2B
BaP 10uM时三者蛋白表达提高
加入MG132后大幅下降
RNA没差
IMR-90
没有差异
Ubiquitination
Post-translational modification
smoker
qPCR
XPA
轻微下降
XPC
轻度吸烟上升 重度吸烟下降
POLD4
轻微下降