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Neurological Conditions - Coggle Diagram

- - - - Tremor
      - Limb rigidity, decreased dexterity
      - Postural reflex impairment
      - Impassive facial expressions
      - Monotonous, hypophonic speech
      - Shuffle
    - - Cognitive deficiencies
      - Depression, anxiety
      - Sleep disturbances, fatigue
      - Pain
      - GIT problems
      - Sexual dysfuncition
  - - - Involved in mitochondrial respiration
      - Oxidative stress, dysfunction
      - Misfolded a-synuclein = Lewy bodies
        
        Aggregate, toxic
    - - Toxic degradation productions
  - - - Carbidopa
        
        Inhibits peripheral dopa decarboxylase
        
        Doesn't cross BBB
      - DA precursor
      - SE
        
        Vomiting, nausea
        
        Orthostatic hypotension, dysrhythmias
        
        Hallucinations
        
        Mood changes (depression, anxiety)
        
        Abnormal motor movement
      - Requires DA neurons, effectiveness declines over time
      - First line, short T1/2, need large doses