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Gram negative Bacilli ( stain pink,endotoxin ) - Coggle Diagram

- - - - disease
        
        enterocolotis 小肠结肠炎( S. enteritidis, typhimurium)
        
        致病因素：
        Dose ( min 10 5)
        Host immune status
        virulence of strain
        6-48 h incubation in small intestine
        
        症状：
        nausea晕船 ,vomit, diarrhea, abdominal pain;
        fever, chills, headache, myalgia
        
        治疗：
        不到万不得已用，不建议Antibiotics，
        会使病症加重
        
        感染来源：
        contaminated food- poultry, eggs, raw meat, milk;
        人传人at home
        
        enteric fever ( thyphi, paratyphi)
        
        S...derivation Typhy- typhoid fever
        S...serotypes Paratyphi A,Hirschfeldii- paratyphoid fever ( milder)
        enteric fever:
        baterial multiplication in lymphoid tissue
        necrosis - ulceration, haemorrhage, perforation
        untreated:
        10%死亡率
        convalescent carriers:
        excrete bacteria for 3 months
        Chronic carriers:
        (1-2%) life long
        diagnosis:
        from blood & stool & urine
        治疗：
        Vaccine available ( 只对一小部分 bacteria 有效）
        not caused by bacterial exotoxin
    - - Most numerous aerobic bacteria in normal gut flora;
        able to form lactose
        as 85% bacteriuria —pathogenic
      - disease-gastroenteritis
        
        Enterotoxigenic E.coli:
        infant & travelers diarrhea
        
        Enteroinvasive E. coli:
        symptoms similar to shigellosis
        
        Enteropathogenic E. coli:
        有名的antigen-
        O157:H7
        disease-
        haemorrhagic colitis,
        hamburger disease (cook well),
    - - Acute diarrhea with mucus , pus, blood stool
        shigella Donnie—Europe & NA
        shigella dysenteriae:
        severe illness
        small numbers cause infection
        found in tropics
        
        治疗：
        No vaccine
    - - Nosocomial infections;医院感染
        infant infected from powdered infant formula
        (pathogen like dry)
  - - - Produce enterotoxin-
        Severe dehydration , death
        secrete chlorides Na+ absorb⬇️
        watery diarrhea
        water-borne 水传播
        10-15 liter /day loss
    - - Except E.colo, maybe one cause of traveller’s diarrhea
        microaerophipic 需氧微生物
        number 1 cause of bacterial gastroenteritis