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Lissencephaly - Coggle Diagram

- - - - more severe posteriorly
      - small brain, tortuous surface vessels, 4 layered cortexm, ectopic olivary nuclei, abnormally convoluted dentate nuclei
      - fetal MRI: very thick smooth cprtex, shallow sylvian fissures, figure 8 shape on axial plane
      - classic type 1 lissencephaly: no associated other major brain or extracerebral anomalias, callosal agenesis uncommon
      - Miller-Dieker sy: codeletion of LIS1 and YHAWAE, dysmorphic facial features, digital abnormalities and retinal hypervascularisation
    - - girls: subcortical band heterotopia - thin/thick - localized/diffuse, normal development/seizure/cognitive impairment
      - boys: X-linked lissencephaly XLIS - fronatl dominance