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Thyroid hormone - Coggle Diagram

- - - - overactive metabolism so
        
        excessive weight loss
        
        sweating
        
        high heart rate
        
        low thyroid stimulating hormone yet high T3 and T4 as the gland is being continually stimulated
      - exophthalmos: bulging eyes due to water retention
  - - - inactive metabolism so:
        
        low tolerance to the cold
        
        gain excessive weight
        
        easily fatigue
        
        slow functions
      - can also see puffiness in the face, hands and feet
  - - - caused by hypothyroidism when:
        the low levels of circulating thyroid hormone that there is no feedback inhibition by the HP-axis
      - caused by hyperthyroidism when:
        it leads to an excess of T3 and T4 secretion
- - - - takes long for effect due to iodine stores
    - - the body can develop a tolerance over time
- - - - lysosome bursts the vesicle and separates the hormones from thyrogobulin
        
        T3 and T4 are secreted into the blood
        
        secretion stimulated by:
        
        cold
        
        trauma
        
        stress
        
        triggers thyrocytes:
        
        increase iodine
        
        increase thyroid peroxidase to iodise the hormones
        
        increase thyroglobulin synthesis
        
        increase colloid uptake
        
        Gs: PKA pathway
        
        Gq: PKC pathway