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rheumatoid arthritis - Coggle Diagram
rheumatoid arthritis
diagnosis
6/10 points based on 4 characteristics of RA
soft spongey joint feeling- thickening of the synovial fluid
testing for rheumatoid factor for differentiating rheumatoid from other types of arthritis
synovial fluid analysis
HLA-DRB1 locus
joint inflammation
swelling
tenderness
warmth
reduced range of motion
collaborative treatment
pain management
maximize mobility
decrease inflammation
prevent bone and cartilage loss
medications
NSAIDs
corticosteroids
biologics (anti- TNFs)
surgery- reduce joint pain
synovectomy
risk factors
females are affected 3x more than men
advanced age >65 onset
genetic predisposition- first degree relatives
human leukocyte antigen loci in the MHC class 2 molecules
presence of rheumatoid factor in their blood
manifestations/ complications
extra- articular
fatigue
anorexia
weight loss
generalized aching and stiffness
occipital headaches
numbness and tingling in the upper extremities
thrombocytosis
anemia
felty syndrome
splenomegaly, neutropenia, and rheumatoid arthritis
joints
joint pain/stiffness
limitation of range of motion- fibrosis
subluxation- dislocation of the joint leading to misalignment of the bone ends
swelling and thickening of the synovium- stretching of the joint, limitation of movement
joint deformities
contractures
instability
baker cyst
difficulty walking
neck discomfort
pathophysiology
diffuse inflammatory lesions and degenerative changes in connective tissue.