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Food Animal Respir Path - Coggle Diagram

- - - - Pasteurella multocida
      - Bordetella bronchiseptica
      - Haemophilus parasuis
      - Streptococcus suis
    - - color: red/purple --> tan/grey
      - firm
      - purulent exudate in bronchi
      - sinks in formalin
    - - bronchioles/alveoli filled w/ neutrophils > macrophages
  - - - Actinobacillus pleuropneumoniae and A. suis
    - - localiz: anywhere in lungs, freq Cd lobes
      - lg areas of hemorrhage/necrosis, sometimes unilat, sometimes one foci
      - pleura: fibrinous pleuritis
    - - oat c "toxic leukocytes" - neutros and macrophages affected by bact leukotoxins
        
        Actinobacillus pleuropneumoniae: Apx I, II, III, IV
        
        Actinobacillus suis: Apx I
  - - - lateral deviation/shortening of snout
      - atrophy of ventral and dorsal turbinates
      - bending of nasal septum
    - - nonprogressive (NPAR)
        
        toxigenic Bordetella bronchiseptica
        
        destroys cilia and epith
      - progressive (PAR)
        
        toxigenic Pastuerella multocida
        
        damage bone struc - inc osteoclastic bone resorp of turbinates
  - - - destruc of cilia
      - immune rxn: recruit of lymphos and M0
      - secondary infec: purulent bronchopneumo
    - - Cr ventral lung consolidation
      - indisting from purulent bronchopneumo
    - - peribronchiolar lymphoid hyperplasia
      - inc in alveolar M0
      - alveolar edema
  - - - virus infects alveolar M0 and impairs bact clear from alveoli
    - - alveolar damage --> necrotic alveolitis
      - thickening of alveolar septa by infil lymphos
    - - lung NOT collapsed
      - rubbery
      - discoloration (multifocal to diffuse)
  - - - swine influenza is type A
    - - H1N1
      - H3N2
      - H1N2
    - - influenza virus infec epith c of trachea, bronchi, and bronchioles >> alveoli
    - - Cr ventral, mutlifocal (patchy, checkerboard) areas of consolidation
      - very unspecific, can be sim to purulent bronchopneumo and M hyo pneumo
    - - bronchointerstitial pneumo
        
        virus infec epith c of trachea, bronchi and bronchioles >> alveoli
        
        necrosis/attenuation of epith: necrotic bronchiolitis
        
        infiltration of bronchial and peribronchial tis w/ lymphos > neutros
        
        secondary bact purulent bronchopneumo is freq
  - - - Haemophilus parasuis: Glasser's dz
        
        arthritis, meningitis
      - Mycoplasma hyorhinis
        
        polyserositis, arthritis
      - Streptococcus suis
        
        meningitis, polyserositis
    - - septicemia
    - - fibrinous pleuritis
      - fibrinous pericarditis
      - fibrinous peritonitis
      - fibrinous/purulent arthritis
    - - same as gross lesions
      - purulent meningitis
- - - - Histophilus somni
      - P. multocida
      - Trueperella pyogenes
      - E. coli
  - - - Mannheimia hemolytica
      - Histophilus somni
      - P. multocida
    - - extensive lesions of Cr ventral lung consol
      - marbling: interstitial edema, areas of hemorrhage/necrosis
      - fibrinous pleuritis
    - - abscesses and pleural adhesions
    - - necrosis of lung tis caused by bact leucotoxin and release of inflamm cytokines
      - lg areas of necrosis surr by "oat c"
  - - - acute, severe necrosis of respir mucosa
        
        nasal, pharyngeal, laryngeal, tracheal, bronchial
      - bronchointerstitial pneumo
        
        more common
        
        can occur w/o URT infec
        
        freq gets complic w/ bact pneumo
  - - - Cr ventral: firm, dk, consol
      - Cd dorsal: hvy, wet, non-collapsed
      - interstitial emphysema
    - - necrotic bronchiolitis w/ bronchiolar epith syncytia
      - prolif alveolitis
  - - - multiple granulomas in dorsoCd, subpleural areas of lung
      - granulomas can merge to form lg areas of necrosis
      - granulomas in tracheobronchial and mediastinal LN
      - granulomas in other organs
    - - granulomas of necrotic center w/ cell debris surr by epith c, multinucleated giant c, fibroblasts, and cnx tis
      - acid fast stain: intracellular acid fast orgm
  - - - hvy, non-collapsed lung
      - multi gray, firm foci
    - - interstitial lymphoplasmacytic infiltration w/ formation of lymphoid follicles
      - alveolar septa are thickened by hypertrophy of smooth musc and cnx tis